• Introduction Geographic factors were also decisive

  2018-11-09

  

  Introduction Geographic factors were also decisive for spatial inequality. The continental size and the geographic heterogeneity of the country compounded with very high transport costs to create wide spatial disparities in the levels of productivity and income per capita. (Azzoni and Ferreira, 199

• In using a gene by

  2018-11-09

  

  In using a gene-by-gene approach combined with Prokka, statins hmg coa reductase inhibitors new to the Lineage 5 genome were discovered. These included the iron receptor complex HpuAB, type IV secretory systems (T4SS) as well as a gonococcal conjugative plasmid. HpuAB receptors enable the acquisiti

• McCaw et al s work adds

  2018-11-09

  

  McCaw et al.\'s work () adds important information to the growing knowledge regarding the effect of lipids on CLL cell biology, however numerous unknowns remain. For example, molecular prognostic markers in the CLL patients in these experiments are not fully detailed, LPL levels are unknown, and ser

• The neuroprotective effect of hypoxic

  2018-11-08

  

  The neuroprotective effect of hypoxic preconditioning in the alk inhibitor has been studied by several groups who found evidence for the involvement of HIF-1α and its downstream targets and/or Epo (He et al., 2008) (Liu et al., 2005; Theus et al., 2008) (Prass et al., 2003) (Bernaudin et al., 2002)

• The interaction between intact AM and limbal

  2018-11-08

  

  The interaction between intact AM and limbal explants does not only degrade the matrix of the AM but also activate intracellular signaling cascades triggered by matrix components. By use of selective pharmacological inhibitors, we investigated the downstream effectors critical for intact AM-induced

• The low percentage of overlap between

  2018-11-08

  

  The low percentage (10%) of overlap between RNA-Seq and ChIP-Seq datasets suggests an alternative role of THAP1 in regulating gene expression other than direct binding at DNA, as exists with other zinc-finger factors (Aguilo et al., 2015). This conclusion may also be supported by the relatively low

• We also showed that the transient suppression of Nanog

  2018-11-08

  

  We also showed that the transient suppression of Nanog by siRNA annulled the self-renewal capacity and tumorigenic activity of GSCs and induced the differentiation of these cells. Recent evidence suggested a shared genomic fingerprint between ESCs, cancer cells, and cancer stem cells. Nanog, Sox2, a

• Acquiring an enriched population of

  2018-11-08

  

  Acquiring an enriched population of a given cell type using a fluorescence-based reporter line has many advantages but requires that the reporter expression is specific to the cell type to be enriched. Glial fibrillary acidic protein (GFAP) is a well-known marker for astrocytes; its expression is dy

• Using ESNPs to repair damaged tissue in neurodegenerative

  2018-11-08

  

  Using ESNPs to repair damaged tissue in neurodegenerative diseases is an attractive option, as these potassium channel blockers are more readily obtained than fetal material. Recent work on the relationship between neural stem cells and blood vessels (reviewed in (Bjornsson et al., 2015) as well as

• miR expression was strikingly down

  2018-11-08

  

  miR-410 expression was strikingly down-regulated in the adult SVZ following Noggin over-expression in our inducible transgenic mice (Morell et al., 2015). Noggin was initially characterized by its ability to rescue the phenotype of UV light-dorsalized embryos (Smith and Harland, 1992; Lamb et al., 1

• To provide optimal sources of NK cells for adaptive

  2018-11-08

  

  To provide optimal sources of NK AMG-517 for adaptive transfer protocol, different methods for cell culture have been developed to expand large numbers of NK cells ex vivo. Cell expansion in cytokine-containing medium with or without stromal feeder cells has been extensively studied by different gro

• br Acknowledgments br Introduction Expression of a defined

  2018-11-08

  

  Acknowledgments Introduction Expression of a defined set of transcription factors (OCT4, SOX2, KLF4, and c-MYC) reprograms human somatic cells to a pluripotent state, generating induced pluripotent stem cells (iPSCs) (Park et al., 2008b; Takahashi et al., 2007; Yu et al., 2007). iPSCs are simi

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-08

  

  Experimental Procedures Acknowledgments Introduction Induced pluripotent stem enolase (iPSCs) can be generated by introducing OCT4, SOX2, KLF4, and c-MYC (Takahashi et al., 2007; Takahashi and Yamanaka, 2006) or other combinations of reprogramming factors (Stadtfeld and Hochedlinger, 2010)

• 4 mu For ESCs on the other hand we

  2018-11-08

  

  For ESCs, on the other hand, we and others recently established that single factors, such as neurogenic differentiation factor 1 (NEUROD1) or neurogenin 2 (NGN2), alone are sufficient to rapidly induce the neuronal fate (Thoma et al., 2012; Zhang et al., 2013). In fibroblasts, however, we had origin

• It was recently shown that hPSCs can

  2018-11-08

  

  It was recently shown that hPSCs can be expanded as cell-only order RPC1063 in serum-free suspension culture irrespective of matrix supplementation (Amit et al., 2011; Olmer et al., 2010; Singh et al., 2010), which is mandatory for conventional surface-attached propagation of hPSCs. In contrast to

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