• The investigators suggest use of doxycycline

  2019-05-28

  

  The investigators suggest use of doxycycline, which is effective for both diseases, as a possible empirical treatment at the primary level of care. Because the consequences of an untreated true case of rickettsiosis or leptospirosis are much greater than are those of unnecessary treatment, Mayxay an

• br For many developing countries investments in health have

  2019-05-28

  

  For many developing countries, investments in health have proved a great success. The Commission “Global health 2035: a world converging within a generation” and the 2014 Gates annual letter envision the possibility of a “grand convergence” by which more countries will have a child mortality rate

• En cuanto a la Accountability

  2019-05-28

  

  En cuanto a la Accountability horizontal, Przeworski planteó que O’Donnell utilizaba el concepto para referirse a que en América Latina las relaciones interinstitucionales, los pesos y contrapesos entre poderes e instancias del Estado eran débiles, por lo cual se terminaban delegando las decisiones

• Outra implica o envolvida com

  2019-05-28

  

  Outra implicação envolvida com as os e que tem sido uma das principais bandeiras levantada por entidades contrárias é leukotriene receptor antagonist considerada terceirização da saúde pública. A terceirização foi assumida por alguns agentes envolvidos no processo, como o ex-secretário de saúde paul

• Conflict of interest br Authors contributions br Acknowledgm

  2019-05-28

  

  Conflict of interest Authors׳ contributions Acknowledgments This work was supported by grants from the Associazione Italiana Lotta alle Leucemie, Linfoma e Mieloma (AIL) – Sezione ‘Luciano Pavarotti’ Modena-ONLUS (to FF and LP) and from the Associazione Italiana per la Ricerca sul Cancro (AIR

• br Contribution br Acknowledgments and disclosures br Introd

  2019-05-28

  

  Contribution Acknowledgments and disclosures Introduction Following HSCT a complex immune reconstitution (IR) is observed. When the infused CD34+cells (CD34+i) begin to proliferate, an increase in peripheral blood ceramide kinase is detected. Lymphocytes require more time than granulocytes

• br With respect to the welfare of children and mothers

  2019-05-28

  

  With respect to the welfare of children and mothers, the transition from the Millennium Development Goals (MDGs) to Sustainable Development Goals (SDGs) is sometimes perceived as risky. The relevant MDGs had a focus on interventions to address maternal and child health, while the focus of the SDGs

• Although these studies demonstrated the

  2019-05-28

  

  Although these studies demonstrated the efficacy of pacemaker treatment for preventing or reducing VVS, all 3 trials were retrospective and uncontrolled [10]. Therefore, RCTs of cardiac pacing in VVS were proposed in the late 1990s. The era of RCTs: is pacemaker efficacy due to a placebo effect?

• In order to treat metastatic

  2019-05-28

  

  In order to treat metastatic bone disease effectively all steps involved in the metastatic cascade need to be taken into account as for example the interactions between primary and secondary sites, tumour cell–bone cell cross talk and osteomimicri [8]. Therefore, concomitant targeting of both the tu

• It is noted that in this study

  2019-05-28

  

  It is noted that in this study BrS patients had an abnormality of plasma K+ concentration which has been suggested to be a potential trigger of Brugada Syndrome episodes [11]. In the absence of renal dysfunction, the hyperkalemia may result from an abnormal phenotype in BrS characterized by mutation

• br Conflict of Interest br Acknowledgments br Introduction H

  2019-05-28

  

  Conflict of Interest Acknowledgments Introduction Human ether-a-go-go-related gene (hERG) encodes the alpha subunit of the rapidly-activating delayed-rectifier K+ channel, which plays a pivotal role in repolarization of cardiac action potentials (APs) [1]. Most of mutant hERG proteins causi

• Paralelamente Chucho Hegel increpa al Profesor Sin dejar de

  2019-05-27

  

  Paralelamente, Chucho Hegel increpa al Profesor: “Sin dejar de ser el mismo, te has convertido en el otro como el blanco que se pinta de negro en el teatro bufo”. Pone, así, sobre el tapete, el que quizá sea el mayor de los demonios contra los que lucha el Profesor, personaje, éste, que deja espacio

• La nueva escritura del Quijote que

  2019-05-27

  

  La nueva escritura del Quijote que emprende Menard resulta a la vez, en gran paradoja, la más fiel y la más infiel, la transcripción total y la adaptación libérrima, y llega incluso a la reducción al absurdo de las leyes del homenaje literario: especie de homenaje por sus antípodas, ya que se omite

• sirtuin inhibitors Introduction By catalyzing post translati

  2019-05-27

  

  Introduction By catalyzing post-translational acetylation of lysine residues, the histone acetyl transferases (HAT) CREBBP and EP300 moderate the activities of both histone and non-histone proteins. This regulates vital cellular processes such as cell cycling and apoptosis by modulating chromatin s

• ERS and BrS are thought to

  2019-05-24

  

  ERS and BrS are thought to represent 2 manifestations of the JWSs. Both syndromes are associated with vulnerability to development of polymorphic VT and VF leading to SCD [1–3,15] in young adults with no apparent structural Annexin V-Cy3 Apoptosis Kit disease and occasionally to sudden infant deat

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