• Introduction Resection remains the mainstay treatment for he

  2018-11-12

  

  Introduction Resection remains the mainstay treatment for hepatocellular carcinoma (HCC). For HCC in the caudate lobe, the resection can be performed as an extension of other types of hepatectomy or as an isolated caudate resection. However, for cases of HCC associated with liver cirrhosis, isolate

• Several studies have confirmed surgical safety margin as a

  2018-11-12

  

  Several studies have confirmed surgical safety margin as a crucial factor that gdc-0980 influenced the survival of patients undergoing traditional or laparoscopic liver resection (Table 3). Occasionally, surgical safety margin could not be secured through the laparoscopic approach. Therefore, a surg

• br Symptoms Some patients with buried penis were

  2018-11-12

  

  Symptoms Some patients with buried penis were circumcised when they presented at clinics. Casale et al reported that 56% of their patients had previously underwent penile surgery, and almost all of them underwent circumcision. In addition, Bergeson et al reported that 42% of their patients underw

• br Materials and Methods br Results

  2018-11-12

  

  Materials and Methods Results Discussion Liver participates in a variety of enzymatic metabolic activities. Administration of ethanol causes elevation of serum ASP, ALT, ALP and total bilirubin levels in rats, indicating that ethanol may induce hepatocellular damages which in turn alters th

• In mESC cultures cells take on

  2018-11-12

  

  In mESC cultures, farnesyl diphosphate synthase take on a mesendodermal fate before being committed to either mesoderm or DE (Tada et al., 2005). Activin is used as a surrogate for nodal as they both activate Smad2/3 signaling via activation of the Alk4 receptor (Schier, 2003). In the mesendoderm p

• The most well studied angiogenic factor that is regulated

  2018-11-12

  

  The most well-studied angiogenic factor that is regulated by hypoxia is VEGF; hypoxic induction of an HIF-1-dependent bFGF autocrine loop drives angiogenesis, over-expression of Ang-1 causes a significant increase in HIF-1 stabilization and PDGF-BB participates in an autocrine-paracrine survival pat

• To investigate whether PD derived HSCs exist in

  2018-11-12

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• br Materials and methods br Author Responsibilities br

  2018-11-12

  

  Materials and methods Author Responsibilities Disclosure Study sponsor Acknowledgments We thank Lucy Brown and Alexander Spalla from the Analytical Cytometry Core, Ricardo Zerda and Zhuo Li from the Electron Microscopy Core, and Dr. Xiwei Wu and Charles Warden from the Integrative Gen

• Molecular ESC analyses and the discovery of iPSC reprogrammi

  2018-11-09

  

  Molecular ESC analyses and the discovery of iPSC reprogramming attributed pluripotency and self-renewal functions to the transcriptional regulators OCT4, SOX2, NANOG, and others (Ivanova et al., 2006; Loh et al., 2006; Takahashi and Yamanaka, 2006). Since then, numerous PGRN versions have been propo

• Because the process of dedifferentiation through the additio

  2018-11-09

  

  Because the process of dedifferentiation through the addition of Yamanaka factors is extremely inefficient, the actual contribution of de novo generated “CSC states” via oncometabolic reprogramming to cancer evolution might be a matter of conjecture. To evaluate such a situation, we first confirmed

• It has previously been reported

  2018-11-09

  

  It has previously been reported that differentiation of hESCs without the embryonic body stage led to an increase in the capacity of hESCs to differentiate into osteogenic progenitor neuropeptide receptors (Karp et al., 2006). Consistent with these findings, our differentiation culture method resul

• Due to specific and well

  2018-11-09

  

  Due to specific and well-characterized genetic tools such as Villin-Cre mice, which allow for epithelium-specific transgene expression or Cre-mediated genetic excision of conditional TAK-875 in the intestine, many studies have focused on late development (Madison et al., 2002; El Marjou et al., 200

• T cell analysis within the spinal

  2018-11-09

  

  T cell analysis within the spinal cord showed a significantly increased number of CD4+ T cells in animals treated with MSC/IL-13. The specific subtype of the T cells is unclear, and previous studies from our group revealed that specific T cell immunophenotyping after CNS injury can be challenging an

• Overall our data support the

  2018-11-09

  

  Overall, our data support the view that the SEZ is a source of plasticity for the adult CC, and that oligodendroblasts could be a valid therapeutic tool for demyelinating diseases if their generation from wider parts of the SEZ could be stimulated, if their response could be sustained for long perio

• br Results br Discussion We have developed an optimized and

  2018-11-09

  

  Results Discussion We have developed an optimized and streamlined method for efficient engineering of targeted chromosomal translocations in human MSCs and iPSCs. We first generated an all-in-one plasmid system to co-express two sgRNAs, the Streptococcus pyogenes Cas9 flanked by two NLSs and a

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