• Our previous studies identified dysfunctional

  2018-10-23

  

  Our previous studies identified dysfunctional sphingolipid metabolism, due to pathological activation of ASM in diabetic retina and bone marrow, as an important metabolic insult contributing to pro-inflammatory changes in the retina and development of diabetic retinopathy (Opreanu et al., 2011; Tikh

• As expected all pups of PBS immunized dams showed neurologic

  2018-10-23

  

  As expected, all pups of PBS-immunized dams showed neurological signs including loss of balance, paresis, and hindlimb paralysis, with 4.62±1.30 of neurological score. However, five out of six pups of MNA-ZIKV-rEfl-immunized dams exhibited neurological illness (no significant difference from the per

• Decitabine br Concluding Remarks br Financial Disclosures br

  2018-10-23

  

  Concluding Remarks Financial Disclosures Author Contributions Role of the Funding Source Partial funding for this study was provided by a service directed grant from the U.S. Department of Veterans Affairs and the University of Minnesota (Brain and Genomics Fund and the American Legion B

• Other interventions inhibit autophagy including inhibitors

  2018-10-23

  

  Other interventions inhibit autophagy, including inhibitors of the protein kinases, ULK1 and ULK2 (Egan et al., 2015, Petherick et al., 2015), and the class III phosphoinositide-3-kinase, (VPS34) (Bago et al., 2014; Dowdle et al., 2014; Ronan et al., 2014). VPS34 is a component of the BCL-2 interact

• Any intravitreally injected substance must prove efficacy an

  2018-10-23

  

  Any intravitreally injected substance must prove efficacy and safety. While our study was not designed as a preclinical safety study, we did not find any obvious structural changes after Sema3f treatment in either of the two in vivo models, which is not surprising given that Sema3f is physiologicall

• Subgroup analysis by ethnicity Asian and Caucasian populatio

  2018-10-23

  

  Subgroup analysis by ethnicity (Asian and Caucasian populations) on RASSF1A promoter methylation in NPC compared with non-tumor tissues showed that methylation was associated with an increased risk of NPC in both Asian and Caucasian populations. These results suggest that RASSF1A, with promoter meth

• Developing an Artificial Bacterial Consortium to Modulate Mi

  2018-10-23

  

  Developing an Artificial Bacterial Consortium to Modulate Microbiota of Frail Elderly The microbial composition of the gut changes gradually with aging and is influenced by habitual diet and health status. In one cohort studied, frail elderly had a microbiota profile characterized by an increase in

• A major question which arises from the aforementioned work

  2018-10-23

  

  A major question which arises from the aforementioned work is if activation of a DDR within telomere repeats indicates physical DNA double stranded breaks or is merely changes in chromatin without an associated lesion. Recently, a new method has been developed which allows the accurate detection of

• Recently several supervised learning methods such as

  2018-10-23

  

  Recently, several supervised learning methods, such as decision trees, have been applied to the analysis of cDNA microarrays to refine prognosis in nasopharyngeal carcinoma, breast cancer and non–small-cell lung cancer.(Chen et al., 2007) State-of-the-art classification algorithms such as support ve

• br Immunolabeling Isolated mitochondria and

  2018-10-23

  

  Immunolabeling Isolated mitochondria and cardiomyocytes (neonatal and adult) were seeded in glass coverslips (0.17-mm thickness) coated with either poly-d-lysine or poly-l-lysine [0.1% (v/v) in PBS], respectively. After, 24h, samples were preloaded with 200nM mitotracker/ER tracker (as described

• Acknowled http www heparin cofactor ii precursor

  2018-10-23

  

  Acknowledgments S.O. and A.C.S were recipient of a fellowship of Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina). V.B., I.E.P., E.M.V., F.C. and R.A. are members of Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina). This work was partially supported by Se

• br Acknowledgements This work was sponsored by the

  2018-10-23

  

  Acknowledgements This work was sponsored by the Rathbone Wine Group, the University of Melbourne, the Australian Wine Research Institute (AWRI), and the Australia Grape and Wine Authority. The work was performed at the University of Melbourne and AWRI and was supported by Australia׳s grape grower

• br Data The data of this

  2018-10-23

  

  Data The data of this article provide the tissue observation of Sprague Dawley (SD) rats which have been treated with normal saline (NS) or rLj-RGD3. Fig. 1 showed the lungs, hearts, livers, spleens and kidneys which were isolated from NS or rLj-RGD3 treated SD rats. In addition, confocal microsc

• br Acknowledgements The authors thank the framework agreemen

  2018-10-23

  

  Acknowledgements The authors thank the framework agreement between the Universidad Nacional de Colombia and Universidad de los Andes (Bogotá, Colombia) under which this work was carried out. They also wish to thank the Bank of the Republic of Colombia and Project 3580 for funding this research.

• br Results and discussion br Conclusions

  2018-10-22

  

  Results and discussion Conclusions Acknowledgements Introduction The fusion welding of heat treatable aluminum alloys has always been a great challenge for designers and technologists. The difficulties associated with these joints are presence of a tenacious aluminum oxide, high thermal

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