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Epithelial mesenchymal transition EMT is the
2024-11-29

Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical lb100 cytoskeleton, lose their junctions and apical-basal polarity, change cell shape, and reprogram gene e
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The small fishers with little
2024-11-29

The small fishers with little or no quota who remained relied on quota leasing arrangements to continue their fishing operations. Such arrangements had relatively high transaction costs and by early 2000 it appeared that the demise of the small fisher was imminent [2]. The introduction in 2001 of t
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br Acknowledgements DHA was funded by
2024-11-29

Acknowledgements DHA was funded by a research grant from Viamet and IMB and DHA were/are consultants for Viamet/Innocrin. DHA also supported by NIH P51-OD011106. Introduction Congenital adrenal hyperplasia resulting from 17alpha-hydroxylase and 17,20-lyase deficiency (17OHD) is a rare autosom
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br Increased blood ATX and LPA in
2024-11-29

Increased blood ATX and LPA in liver fibrosis Although previous in vitro findings have suggested a link between LPA and liver fibrosis in vivo, whether LPA plays a primary role in the pathogenesis of liver fibrosis has remained uncertain. No phenotypic changes in livers of LPA receptor-deficient
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br Acknowledgements br Introduction Thus damage to the nervo
2024-11-29

Acknowledgements Introduction Thus, damage to the Terbinafine may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regenerate after letha
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br ACL Inhibition Lowering Blood LDL C to
2024-11-28

ACL Inhibition: Lowering Blood LDL-C to Reduce ASCVD Risk Given its strategic position in the lipid biosynthesis pathway, ACL has been considered an attractive target for lipid-lowering even before statins and their effects on cholesterol homeostasis were elucidated (Box 2). Cells carefully maint
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br Experimental Section br Results and Discussion br
2024-11-28

Experimental Section Results and Discussion Conclusions The advantages of the novel enzymo-chemical method for Mn and Co assay are simplicity of analytical procedure and economic effect due to the usage of only one enzyme in the form of apo-enzyme. An effectiveness of the apo-arginase-based
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br Materials and methods br Results br Discussion
2024-11-28

Materials and methods Results Discussion Our results revealed that LPS injection in rats impaired fear memory in the PA task. This results are in agreement with the most of previous studies reported that following acute [23,24,39,[45], [46], [47]] or chronic systemic StemRegenin 1 [30] fea
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The amino acids evaluated in this
2024-11-28

The amino acids evaluated in this study represent proteinogenic (amino acids that are applied in the genetic code) or even essential ones (amino acids that cannot be synthesised by the organism and need to be taken up by nutrition). Tryptophan, phenylalanine, tyrosine, isoleucine, threonine and vali
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One of the specifications of the NIA AA research
2024-11-28

One of the specifications of the NIA-AA research framework was that it sr 75 receptor be applicable in two distinct research contexts—interventional trials and observational research. In many if not most modern AD interventional trials, individuals are selected for inclusion with the aid of biomark
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br Stress glucocorticoids as risk factor for Alzheimer s
2024-11-28

Stress/glucocorticoids as risk factor for Alzheimer’s Disease: preclinical studies A role for glucocorticoids in shaping the risk for AD is supported by animal studies using rats or mice injected with Aβ oligomers, tau protein or excitotoxins, or transgenic (Tg) mice carrying mutations associated
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br Concluding Remarks and Future Perspectives br Disclaimer
2024-11-28

Concluding Remarks and Future Perspectives Disclaimer Statement Introduction Aldehyde dehydrogenase ALDHs (E.C. 1.2.1.3) are multigene family of NAD(P)+-dependents group of structurally and functionally related ubiquitously distributed enzymes involved in the specific and irreversible oxida
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Analyses of brain CSCs isolated from pediatric and
2024-11-28

Analyses of tcy CSCs isolated from 24 pediatric and six adult brain tumors detected ALDH levels proportional to tumor type and aggressiveness. ALDH-expressing cells (ALDH+) formed spheroids while ALDH1 pharmacological inhibition by a combination of DEAB and RA decreased significantly sphere number
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This study revealed that EAAT expression was increased weeks
2024-11-28

This study revealed that EAAT2 Nevirapine was increased 4–8 weeks after cauterization as our previous work (Park et al., 2009). RGC death could not be blocked despite activation of EAAT2, which is one of glutamate transporters in cone photoreceptors and some bipolar cells, in chronic ocular hyperten
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br Discussion With recently improved understanding of the
2024-11-28

Discussion With recently improved understanding of the role of βARK1 in the progression of HF and as a potential therapeutic target in HF, we explored the relationship between plasma βARK1, as a marker of chronic sympathetic overactivation, and physical symptoms in HF. Our main findings were 1) e
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